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  Karmanos has had a successful business career as well. He launched Compuware (Nasdaq: CPWR) in 1973, joining two partners who invested $3,000 each to build a small company that would help businesses work with computers. Today, the company has more than 4,500 employees and earns more than $1 billion in annual revenue. He was awarded the National Management Association (NMA) Hall of Fame Award last year.

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  The Dow Industrials ended down 1.38 points or 0.01 percent at 15,521, while the S&P 500 Index closed 0.63 points or 0.04 percent higher at 1,686. The Nasdaq Composite managed to hold above the unchanged line throughout the session despite some weakness emerging in late afternoon trading. The index closed at 3,617, up 17.33 points or 0.48 percent.

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  Those disappointments come on top of years of trying -- and failing -- at other promising approaches. The plaques that clog the brains of Alzheimer's patients seem to be accelerated by high cholesterol in the blood. So researchers tried cholesterol-lowering drugs in Alzheimer's patients. That didn't work. Doctors noticed that the brains of people with Alzheimer's are very inflamed, so researchers mounted large trials to test over-the-counter anti-inflammatory medications against memory loss. They were of no help.

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